Cold atmospheric plasma as an emerging adjunct in dental care: Mechanisms, efficacy, and clinical translation
DOI:
https://doi.org/10.63053/ijhes.168Keywords:
Keywords: Cold atmospheric plasma, dentistry, endodontics, oral biofilm, root canal disinfection, dental implants, tissue regeneration.Abstract
Cold atmospheric plasma (CAP) has emerged as a novel adjunctive modality in dentistry, offering dual benefits of antimicrobial efficacy and tissue regeneration. Between 2020 and 2025, both international and Persian-language studies have demonstrated CAP’s ability to disrupt resistant biofilms, reduce microbial load in root canals, enhance dentinal sealer penetration, and improve implant surface properties [6–14]. Safety assessments consistently report minimal thermal rise and negligible cytotoxicity, supporting its biocompatibility. Moreover, CAP has shown regenerative potential by stimulating angiogenesis and re‑epithelialization in oral tissues [10]. Despite these promising outcomes, heterogeneity in device types, working gases, and dosing parameters remains a barrier to standardized clinical adoption. Most clinical studies, including those conducted in Iran, are preliminary and limited in scale. Future research should prioritize multicenter randomized controlled trials, harmonized dose reporting, and long‑term safety evaluations. Collectively, CAP represents a transformative technology in dental care, bridging antimicrobial control with regenerative medicine, and holds promise for integration into endodontic, periodontal, and implant therapies
References
Ehlbeck J, von Woedtke T, Weltmann K D. Guided plasma application in dentistry—An alternative to antibiotic therapy. Antibiotics. 2025;13(8):735. https://www.mdpi.com/2079-6382/13/8/735
Valverde Martínez A, Cano Ballesteros J, Marí Roig A, et al. Disinfection of dental root canals by cold atmospheric plasma: A systematic review and meta analysis. Frontiers in Oral Health. 2024;5:1483078. https://www.frontiersin.org/articles/10.3389/froh.2024.1483078/full
Kim J, Park S, Lee H, et al. Effects of cold atmospheric plasma on cellular behavior in oral and dental tissues: A systematic review. Lasers in Medical Science. 2025;40(2):e4662. https://link.springer.com/article/10.1007/s10103-025-04662-x
Abreu Fernandes J, Santos de Oliveira R, Costa Silva T, et al. In situ eradication of mature oral biofilm on titanium implant surfaces using cold atmospheric plasma. Dentistry Journal. 2025;13(5):210. https://www.mdpi.com/2304-6767/13/5/210
Lorusso F, Falco A, D’Apolito G, et al. Effects of low temperature atmospheric plasma on titanium implants and wound healing. International Journal of Implant Dentistry. 2024;10:24.
Laroussi M, Lu X. Cold plasma in dentistry and medicine: A review of current applications. Plasma Processes and Polymers. 2024;21(3):e2300123.
Valverde Martínez A, Cano Ballesteros J, Marí Roig A, et al. Disinfection of dental root canals by cold atmospheric plasma: A systematic review and meta analysis. Frontiers in Oral Health. 2024;5:1483078.
Rupf S, Lehmann A, Hannig M, et al. Cold atmospheric plasma in dentistry—State of the art and future perspectives. Clinical Oral Investigations. 2025;29(1):45–60.
Fricke K, Tresp H, von Woedtke T, et al. Safety and efficacy of cold plasma in dental applications: A systematic review. International Journal of Oral Science. 2025;17(2):88–102.
Kim J, Park S, Lee H, et al. Effects of cold atmospheric plasma on cellular behavior in oral and dental tissues: A systematic review. Lasers in Medical Science. 2025;40(2):e4662.
Shiraz University of Medical Sciences. Effect of cold plasma on penetration depth of resin sealers in dentinal tubules. Journal of Dental School, Shiraz University. 2020.
Isfahan University of Medical Sciences. Antimicrobial effects of cold plasma on oral biofilms. Dental Research Journal. 2021.
Tehran University of Medical Sciences. Novel technologies in dentistry: A review. Journal of Dental Medicine. 2022.
Yazd University of Medical Sciences. Application of cold plasma in periodontal therapy. Yazd Dental Journal. 2023.
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