Dual Role of Cold Atmospheric Plasma in Skin Cancer Therapy and Wound Healing
DOI:
https://doi.org/10.63053/ijhes.169Keywords:
Keywords: Cold atmospheric plasma, skin cancer therapy, wound healing, angiogenesis, fibroblast migration, biocompatibilityAbstract
Abstract
Innovative therapeutic strategies in dermatological oncology increasingly focus on modalities that combine tumor suppression with tissue regeneration. Among these, cold atmospheric plasma (CAP) has demonstrated a unique dual role in both skin cancer therapy and wound healing. CAP generates reactive oxygen and nitrogen species (ROS/RNS), ultraviolet photons, and transient electric fields, which selectively induce apoptosis in malignant cells while preserving normal keratinocytes and fibroblasts. This selectivity is linked to differences in redox balance and DNA repair capacity between cancerous and healthy tissues. In addition to its tumoricidal activity, CAP enhances wound healing by stimulating angiogenesis, promoting fibroblast migration, and accelerating epithelial regeneration. Evidence from international and Persian-language studies highlights CAP’s biocompatibility and minimal genotoxicity, though variability in plasma devices, working gases, and treatment parameters complicates cross-study comparisons. Long-term safety data remain limited, underscoring the need for standardized protocols and translational research. This review integrates mechanistic insights, cellular safety profiles, and clinical perspectives, positioning CAP as a promising adjunct to conventional therapies in the management of cutaneous malignancies and wound repair.
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