Investigating the effect of resveratrol on the survival rate of 4T1 breast cancer cells by MTT method

Zahra Sadat Abbas Miri; Nazanin Zahra Takhti; Fatemeh Sadat Hassaneini; Kiana Kavehbakhshayesh

doi:10.63053/ijhes.89

Authors

Zahra Sadat Abbas Miri Department of Biology, Iran Nuclear Industry Institute, Tehran, Iran
Nazanin Zahra Takhti Department of Biology, Nedaya Reyhaneh Educational Institute, Tehran, Iran
Fatemeh Sadat Hassaneini Department of Biology, Iran Nuclear Industry Institute, Tehran, Iran
Kiana Kavehbakhshayesh Department of Biology, Iran Nuclear Industry Institute, Tehran, Iran

DOI:

https://doi.org/10.63053/ijhes.89

Keywords:

Resveratrol, 4T1 Cancer cell, MTT

Abstract

Cancer is known as an incurable, deadly and deadly disease with pain and disability. During recent decades, changes in people's lifestyles have increased the incidence and prevalence of breast cancer worldwide. With the wide spread of this disease, research has also increased on this issue. Resveratrol is known as a natural polyphenol found in red grapes and some other foods, and with its important anti-cancer properties, it can be effective in reducing the risk of breast cancer and its treatment. Research has shown that resveratrol can have positive effects on breast cancer by reducing DNA methylation, reducing cell proliferation, and reducing cancer growth factors. In this research, resveratrol has been used against 4T1 cancer cells, which were treated with different concentrations of resveratrol after cultivation in 96-well plates and measured by the MTT method. The obtained results showed that resveratrol in all concentrations and at different times significantly reduces the survival of 4T1 cancer cells. By increasing the concentration and treatment time, the decrease in cell viability increases. This indicates strong, dose- and time-dependent effects of resveratrol on breast cancer cells.

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